C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/46 (2006.01) C12N 9/18 (2006.01) C12Q 1/46 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2433057
The invention provides twenty-five butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries of butyrylcholinesterase variants as well as libraries of the corresponding nucleic acids encoding butyrylcholinesterase variants. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
La présente invention concerne vingt cinq variants de butyrylcholinestérase présentant une activité hydrolytique de la cocaïne accrue, ainsi que les acides nucléiques codants associés. Cette invention concerne également des bibliothèques de variants de butyrylcholinestérase, ainsi que des bibliothèques des acides nucléiques correspondants codant des variants de butyrylcholinestérase. Enfin, cette invention concerne des méthodes permettant d'hydrolyser un substrat de butyrylcholinestérase à base de cocaïne, ainsi que des méthodes permettant de traiter un état induit par la cocaïne.
Lockridge Oksana
Pancook James D.
Watkins Jeffry D.
Applied Molecular Evolution Inc.
Board Of Regents Of The University Of Nebraska
Gowling Lafleur Henderson Llp
LandOfFree
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