Butyrylcholinesterase selective inhibitors

Details Butyrylcholinesterase selective inhibitors Butyrylcholinesterase selective inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/454 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2566594

The invention provides butyrylcholinesterase inhibitors of formula (I), which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the treatment and/or prophylaxis of cognitive disorders and/or neurodegenerative disorders.

L'invention concerne des inhibiteurs de butyrylcholinestérase de formule (I), renfermant une fraction hétérocyclique et une fraction de 4 pipéridine reliées par un élément de liaison. Ces composés assurent une activité et une sélectivité soutenues vis-à-vis de BuChE, ce qui les rend utiles pour le traitement et/ou la prévention des troubles cognitifs et/ou neurodégénératifs.

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