A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/46 (2006.01) C07H 21/04 (2006.01) C12N 9/18 (2006.01)
Patent
CA 2518529
The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine- induced condition with the invention variant.
La présente invention a trait à un variant de butyrylcholinestérase présentant une activité d'hydrolyse de cocaïne accrue ainsi que l'acide nucléique codant correspondant. L'invention a également trait à des procédés d'hydrolyse d'un substrat de butyrylcholinestérase à base de cocaïne ainsi que des procédés de traitement de condition induite par la cocaïne mettant en oeuvre le variant de l'invention.
Pancook James D.
Watkins Jeffry D.
Applied Molecular Evolution Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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