Bv8 nucleic acids and polypeptides with mitogenic activity

Details Bv8 nucleic acids and polypeptides with mitogenic activity Bv8 nucleic acids and polypeptides with mitogenic activity

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A01N 37/18 (2006.01) A01N 43/04 (2006.01) A61K 38/00 (2006.01) C07K 14/475 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2458670

The present invention provides methods of using Bv8 polypeptides to induce endothelial cell proliferation and to enhance endothelial cell survival. Also provided herein are methods of screening for modulators of Bv8 activity. Furthermore, methods of treatment using Bv8 polypeptides are provided.

L'invention concerne des procédés d'utilisation de polypeptides Bv8 permettant d'induire une prolifération cellulaire endothéliale et d'augmenter la survie de cellules endothéliales. Elle concerne aussi des procédés de criblage de modulateurs de l'activité de Bv8. Elle concerne enfin des méthodes de traitement utilisant des polypeptides Bv8.

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