C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/14 (2006.01) C07D 305/14 (2006.01)
Patent
CA 2718567
Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3') and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3'), pharmaceutical compositions comprising such taxanes, methods of treatment and administration, and methods of preparation of medicaments comprising the taxanes.
La présente invention concerne des taxanes ayant un substituant dester éthylique ou dester cyclopropylique en C(10), un substituant céto en C(9), un substituant hydroxy en C(7), un substituant thiényle en C(3') et un substituant cyclobutyloxycarbamate ou cyclopentyloxycarbamate en C(3'), des compositions pharmaceutiques comprenant de tels taxanes, des procédés de traitement et dadministration, et des procédés de préparation de médicaments comprenant les taxanes.
Holton Robert A.
Vu Phong
Florida State University Research Foundation Inc.
Smart & Biggar
LandOfFree
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