C-2' hydroxyl-benzyl protected, n-carbamate protected...

Details C-2' hydroxyl-benzyl protected, n-carbamate protected... C-2' hydroxyl-benzyl protected, n-carbamate protected...

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01)

Patent

CA 2222421

The invention relates to the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side chain acid to produce an intermediate that may thereafter be acylated and deprotected to produce paclitaxel.

La présente invention concerne la semi-synthèse du paclitaxel au moyen d'un squelette protégé de baccatine III qui est estérifié avec un acide à chaîne latérale convenablement protégé pour produire un composé intermédiaire, qui peut ensuite être acylé et déprotégé pour donner du paclitaxel.

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