C-4 carbonate taxanes

Details C-4 carbonate taxanes C-4 carbonate taxanes

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/337 (2006.01)

Patent

CA 2399116

The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations. The invention claims compounds of formula (I) and the use of compounds of formula (I) or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease, in which: R is phenyl, isopropyl, or tert butyl; R1 is - C(O)RZ in which RZ is (CH3)3CO-, (CH3)3CCH2-, CH3(CH2)3O-, cyclobutyl-, cyclohexyloxy, or (2-furyl); R2 is CH3C(O)O-.

L'invention concerne de nouveaux dérivés du taxane, leur utilisation en tant qu'agents antitumoraux et des formulations pharmaceutiques. D'une manière plus spécifique, l'invention concerne des composés représentés par la formule (I) et leur utilisation ou leurs sels pharmaceutiquement acceptables en tant que médicaments à administration orale pour le traitement de maladies humaines ou animales. Dans cette formule, R représente phényle, isopropyle ou tert-butyle; R?1¿ représente C(O)R?Z¿ dans lequel R?Z¿ représente (CH¿3?)¿3?CO-, (CH¿3?)¿3?CCH¿2?-, CH¿3?(CH¿2?)¿3?O-, cyclobutyl-, cyclohexyloxy, ou (2-furyle); R?2¿ représente CH¿3?C(O)O-.

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