A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2374990
The present invention relates generally to the fields hyperproliferative disease and angiogenesis. More particularly, the present invention demonstrates that a C-CAM1 cytoplasmic domain is necessary and sufficient for inhibiting angiogenesis. In particular embodiments, it relates to inhibiting hyperproliferative cell growth by administering to a cell a C-CAM1 cytoplasmic domain or an expression construct encoding a C-CAM1 cytoplasmic domain. In other embodiments, angiogenesis is inhibited by administering to a subject a C- CAM1 polypeptide or an expression construct encoding a C-CAM1 polypeptide.
Cette invention se rapporte de manière générale au domaine des maladies hyper-proliférantes et de l'angiogenèse. Plus précisément, cette invention a permis de démontrer qu'un domaine cytoplasmique C-CAM1 était nécessaire et suffisant pour inhiber l'angiogenèse. Dans des modes de réalisation particuliers, cette invention consiste à inhiber la croissance cellulaire hyper-proliférante en administrant à une cellule un domaine cytoplasmique C-CAM1 ou une construction d'expression qui code un domaine cytoplasmique C-CAM1. Dans d'autres modes de réalisation, l'angiogenèse est inhibée par l'administration à un sujet d'un polypeptide C-CAM1 ou d'une construction d'expression qui code un polypeptide C-CAM1.
Lin Sue-Hwa
Logothetis Christopher
Luo Weiping
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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