C-class oligonucleotide analogs with enhanced...

Details C-class oligonucleotide analogs with enhanced... C-class oligonucleotide analogs with enhanced...

C - Chemistry, Metallurgy

12

N

C12N 15/117 (2010.01) A61K 39/39 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) C12N 15/11 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2540949

The invention relates to a class of CpG immunostimulatory oligonucleotides containing a CpG immunostimulatory motif and a second motif which is capable of forming secondary structure, including duplex and higher order structures, in vitro and in vivo. The oligonucleotides of the invention are useful as adjuvants in vaccination. The oligonucleotides are also useful for inducing an immune response, inducing expression of a type I interferon (IFN), inducing expression of gamma interferon (IFN-.gamma.), and for treating a variety of conditions, including allergy, asthma, infection, and cancer.

L'invention concerne une catégorie d'oligonucléotides immunostimulateurs CpG contenant un motif immunostimulateur CpG et un deuxième motif pouvant former une structure secondaire, notamment des structures duplex et d'ordre élevé, in vitro et in vivo. Les oligonucléotides selon l'invention sont utiles en tant qu'adjuvants pour la vaccination. Ces oligonucléotides servent également à induire une réponse immunitaire, à induire l'expression d'un interféron de type I (INF), à induire l'expression d'un interféron gamma (INF-.gamma.), et à traiter divers états, notamment les allergies, l'asthme, les infections et le cancer.

Affiliated with

Also associated with

Rating

C-class oligonucleotide analogs with enhanced... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-class oligonucleotide analogs with enhanced..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-class oligonucleotide analogs with enhanced... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1377393