C-kit modulators and methods of use

Details C-kit modulators and methods of use C-kit modulators and methods of use

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/341 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2536954

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Even more specifically, the invention provides compounds for modulating c-Kit kinase activity and methods of treating diseases mediated by c-Kit activity utilizing the compounds and pharmaceutical compositions thereof.

L'invention concerne des composés de modulation de l'activité enzymatique de la protéine kinase en vue de la modulation des activités cellulaires, notamment la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chimio-invasion. L'invention concerne de manière plus spécifique des composés de modulation de l'activité de la kinase c-Kit et leurs méthodes de traitement de maladies induites par l'activité de c-Kit utilisant les composés et leurs compositions pharmaceutiques.

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