C-met modulators and methods of use

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/233 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) C07D 239/88 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C12Q 1/48 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2537812

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c- Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

La présente invention se rapporte à des composés permettant de moduler l'activité enzymatique des protéines kinases aux fins de la modulation d'activités cellulaires telles que la prolifération, la différenciation, la mort programmée des cellules, la migration et la chimio-invasion. Plus spécifiquement, l'invention se rapporte à des quinazolines et à des quinolines qui inhibent, régulent et/ou modulent les récepteurs kinases, notamment c-Met, KDR, c-Kit, flt-3 et flt-4, à des voies de transduction du signal associées aux changements d'activités cellulaires telles que mentionnées ci-dessus, à des compositions qui contiennent ces composés, et à des procédés d'utilisation de ces compositions pour traiter des maladies et des troubles dépendants des kinases. La présente invention se rapporte également à des procédés de fabrication de composés tels que ceux décrits ci-dessus, et de compositions qui contiennent ces composés.

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