C-myc antisense-treated hematopoietic stem cell composition...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/0789 (2010.01) A61K 35/14 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) A61K 31/7088 (2006.01) A61K 38/19 (2006.01)

Patent

CA 2386192

A composition comprising increased numbers of hematopoietic stem cells (HSC) prepared by treating an enriched population of HSC with a c-myc antisense oligonucleotide is described. The invention further relates to methods for producing the same and the use of c-myc antisense oligonucleotide-treated HSC as a medicament.

L'invention concerne une composition contenant un nombre augmenté de cellules souches hématopoïétiques (HSC) préparée par traitement d'une population enrichie de cellules souches hématopoïétiques (HSC) avec un oligonucléotide antisens c-myc). L'invention concerne également des procédés de fabrication de cette composition et l'utilisation de cellules souches hématopoïétiques (HSC) traitées avec un oligonucléotide antisens c-myc, en tant que médicament.

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