C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/7064 (2006.01) A61P 31/14 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C07D 498/04 (2006.01) C07H 7/06 (2006.01) C07H 19/16 (2006.01)
Patent
CA 2568379
The present invention provides C-purine nucleoside analogs and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such C-nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the C- nucleoside compounds of the present invention.
L'invention concerne des analogues nucléosidiques de c-purine et certains de leurs dérivés qui inhibent l'ARN-polymerase virale ARN-dependante. Ces composés sont des inhibiteurs de la réplication virale d'ARN ARN-dépendante, et sont utiles pour le traitement d'une infection virale ARN ARN-dépendante. Ces composés sont particulièrement utiles en tant qu'inhibiteurs de la polymérase NS5B du virus de l'hépatite C (HCV), en tant qu'inhibiteurs de la réplication du HCV, et/ou pour le traitement d'une infection par l'hépatite C. L'invention concerne également des compositions pharmaceutiques contenant des composés C-nucléosidiques seuls ou combinés à d'autres agents actifs contre une infection virale ARN ARN-dépendante, en particulier une infection HCV. L'invention concerne encore des méthodes d'inhibition de l'ARN-polymérase ARN-dépendante, d'inhibition de la réplication virale ARN ARN-dépendante, et/ou de traitement d'une infection virale ARN ARN-dépendante, à l'aide des composés C-nucléosidiques susmentionnés.
Bhat Balkrishen
Butora Gabor
Eldrup Anne B.
Maccoss Malcolm
Gowling Lafleur Henderson Llp
Isis Pharmaceuticals Inc.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
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