C-reactive protein (crp) knockout mouse

Details C-reactive protein (crp) knockout mouse C-reactive protein (crp) knockout mouse

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2675100

The instant invention relates to a transgenic, non-human animal that carries a mutation in the gene encoding C-reactive protein (CRP). Preferably, the invention relates to an animal comprising a homozygous CRP-deficient mouse and techniques for producing such animals. The invention also relates to organs, tissues, cells, cell lines and sub-cellular fractions derived from such animals. Techniques for generating total or tissue-specific CRP knockout animals are also described. The invention further relates to the use of such knockout animals for the study of the role of CRP proteins in vivo or ex vivo, particularly in relation to its role in inflammatory pathway and in the etiology human diseases.

La présente invention concerne un animal non humain transgénique portant une mutation dans le gène codant pour la protéine C réactive (CRP). De préférence, l'invention concerne un animal comportant une souris homozygote déficiente en CRP et des techniques pour produire de tels animaux. L'invention concerne également des organes, des tissus, des cellules, des lignées cellulaires et des fractions sous-cellulaires dérivés de tels animaux. L'invention concerne en outre des techniques de génération d'animaux à déficience en CRP totale ou spécifique du tissu. L'invention concerne aussi l'utilisation de tels animaux knockout pour l'étude du rôle des protéines CRP in vivo ou ex vivo, notamment concernant son rôle dans la voie inflammatoire et dans l'étiologie des maladies humaines.

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