C-ring-substituted pregn-4-ene-21,17-carbolactones, and...

Details C-ring-substituted pregn-4-ene-21,17-carbolactones, and... C-ring-substituted pregn-4-ene-21,17-carbolactones, and...

C - Chemistry, Metallurgy

07

J

C07J 53/00 (2006.01) A61K 31/58 (2006.01) A61P 5/28 (2006.01) A61P 5/34 (2006.01) A61P 5/42 (2006.01)

Patent

CA 2726855

The present invention relates to C-ring-substituted pregn-4-ene-21,17- carbolactones of the general formula I See Formula I in which R6,7 is an .alpha.- or .beta.-methylene and R9 is a hydrogen atom and R11 is a bromine, chlorine or fluorine atom or R9 and R11 together are a bond. The novel compounds are progestational antimineralocorticoids.

La présente invention concerne des pregn-4-en-21, 17 carbolactones substitués sur le noyau C de la formule générale I dans laquelle R6,7 représente un méthylène en position a ou ß et R9 représente un atome d'hydrogène et R11 représente un atome de brome, de chlore ou de fluor ou R9 et R11 représentent ensemble une liaison. Les nouveaux composés sont des antiminéralocorticoïdes gestagènes.

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