C-terminal .alpha.-amidating enzyme and process for...

Details C-terminal .alpha.-amidating enzyme and process for... C-terminal .alpha.-amidating enzyme and process for...

C - Chemistry, Metallurgy

12

N

195/39.1

C12N 9/02 (2006.01)

Patent

CA 1337860

A C-terminal .alpha.-amidating enzyme of porcine origin having the following properties: (1) Action and substrate specificity: acting on a peptide or protein represented by the formula, X-R-Gly wherein Gly represents a C-terminal glycine residue, R represents an amino acid residue to be .alpha.-amidated and X represents a remaining portion of the peptide or protein to convert it to a peptide or protein represent by the formula X-R-NH2 wherein R-NH2 represents a C-terminal .alpha.-amidated amino acid residue and X represents a residual portion of the peptide or protein; (2) optimum pH: 6.5 to 8.5; (3) molecular weight: about 92,000 as determined by SDS-polyacrylamide gel electrophoresis; and (4) containing the following peptide fragment: ...Glu-Ala-Pro-Leu-Leu-Ile-Leu-Gly....; and a process for the production of the C-terminal .alpha.-amidating enzyme comprising the step of extracting and purifying the enzyme from porcine atrium cordis exhibiting the enzyme activity.

593643

Affiliated with

Also associated with

Rating

C-terminal .alpha.-amidating enzyme and process for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with C-terminal .alpha.-amidating enzyme and process for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and C-terminal .alpha.-amidating enzyme and process for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1188622