C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2637719
The present invention relates to a novel C-terminal exon of RUNX1/AML1, its nucleic acid sequence, its peptide and a full length amino acid sequence comprising the novel C-terminal exon. Furthermore, the invention is directed to an antibody against the C-terminal exon of RUNX1/AML1 , a pharmaceutical composition for the treatment of various diseases, among others various tumours and the use of the C-terminal exon for the manufacture of a medicament. The C-terminal exon may also be used for the inhibition of cellular growth and/or induction of apoptosis. Furthermore, the invention relates to a method and a kit for diagnosing a disease, both using the C- terminal exon.
La présente invention concerne un nouvel exon 5.4 C-terminal de RUNX1/AML, sa séquence d'acide nucléique, ses peptides, et une séquence d'acides aminés pleine longueur comprenant le nouvel exon C-terminal. L'invention concerne également un anticorps dirigé contre l'exon C-terminal de RUNX1/AML, une composition pharmaceutique destinée au traitement de diverses maladies, entre autres diverses tumeurs, et l'utilisation de l'exon C-terminal pour la production d'un médicament. L'exon C-terminal peut être également utilisé pour inhiber la croissance cellulaire et/ou induire l'apoptose. L'invention concerne en outre une méthode et une trousse de diagnostic d'une maladie, qui utilisent toutes deux l'exon C-terminal.
Gattenloehner Stefan
Marx Alexander
Julius-Maximilians-Universitaet Wuerzburg
Kirby Eades Gale Baker
LandOfFree
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