C-terminal modified (n-substituted)-2-indolyl dipeptides as...

Details C-terminal modified (n-substituted)-2-indolyl dipeptides as... C-terminal modified (n-substituted)-2-indolyl dipeptides as...

C - Chemistry, Metallurgy

07

K

C07K 5/078 (2006.01) A01N 1/02 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61K 38/55 (2006.01) C07K 5/02 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2265928

This invention is directed to novel (N-substituted)indole ICE/ced-3-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.

Cette invention se rapporte à de nouveaux composés d'indole (N-substitué), inhibiteurs de la famille ICE/ced-3. Elle se rapporte notamment à des compositions pharmaceutiques de tels composés d'indole, ainsi qu'à l'utilisation de telles compositions s'agissant de traiter des patients atteints de maladies inflammatoires, auto-immunes et neurodégénératives et de prévenir les ischémies.

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