C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/22 (2006.01) A61K 31/33 (2006.01) A61K 38/00 (2006.01) A61K 38/05 (2006.01) A61K 38/06 (2006.01) A61P 7/06 (2006.01) A61P 9/10 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) A61P 43/00 (2006.01) C07C 235/80 (2006.01) C07C 317/50 (2006.01) C07D 209/42 (2006.01) C07D 211/60 (2006.01) C07D 235/30 (2006.01) C07D 237/22 (2006.01) C07D 239/00 (2006.01) C07D 239/34 (2006.01) C07D 261/18 (2006.01) C07D 309/30 (2006.01) C07D 311/32 (2006.01) C07F 9/32 (2006.01) C07F 9/46 (2006.01)
Patent
CA 2336474
This invention is directed to novel oxamyl depeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.
La présente invention concerne de nouveaux oxamyl dipeptides qui inhibent la famille Ice/ced-3 des protéases de cystéine. L'invention concerne également des compositions pharmaceutiques renfermant ces composés ainsi que l'emploi de ces compositions pour le tacitement de patients souffrant de maladies inflammatoires, auto-immunes et neurodégénératives, pour la prévention des lésions ischémiques et pour la conservation d'organes destinés à une transplantation.
Karanewsky Donald S.
Ternansky Robert J.
Gowling Lafleur Henderson Llp
Idun Pharmaceuticals Inc.
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