C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2314971
Novel polypeptides derived from the C-terminal region of the human and mouse agouti related transcript (ART) proteins are provided. Also provided are DNA sequences encoding the novel C-terminal polypeptides. The novel C-terminal polypeptides can be used to inhibit the binding of melanocyte stimulating hormones to melanocortin receptors. Methods of identifying inhibitors of the binding of ART protein to melanocortin receptors are also provided.
L'invention concerne de nouveaux polypeptides dérivés de la région C-terminale de protéines du transcript lié à l'agouti (ART) chez l'homme et chez la souris. L'invention concerne également des séquences d'ADN codant les nouveaux polypeptides de C-terminal. Les nouveaux polypeptides de C-terminal peuvent s'utiliser pour inhiber la liaison d'hormones mélanotropes aux récepteurs de mélanocortine. L'invention concerne enfin des méthodes d'identification d'inhibiteurs de liaison de protéines d'ART aux récepteurs de mélanocortine.
Fong Tung Ming
Tota Michael R.
Van Der Ploeg Leonardus H.t.
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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