C-terminally truncated cftr genes and proteins

Details C-terminally truncated cftr genes and proteins C-terminally truncated cftr genes and proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2186122

Provided are novel DNA molecules that include a nucleotide sequence encoding novel truncated CFTR polypeptides that have functional Cystic Fibrosis transmembrane conductance regulator (CFTR) protein biological activity. Also provided are the novel truncated CFTR polypeptides that possess the functional CFTR biological activity. The novel polypeptides act as regulated epithelial cell anion (Cl-) channels.

Nouvelles molécules d'ADN comportant une séquence nucléotidique codant des nouveaux polypeptides tronqués régulateurs de la conductance transmembranaire de la fibrose kystique (CFTR) présentant l'activité biologique des protéines fonctionnelles CFTR, et des nouveaux polypeptides CFTR tronqués présentant une activité biologique CFTR fonctionnelle et se comportant comme des canaux d'anions (Cl?-¿) régulés de cellules épithéliales.

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