C-terminally truncated interferon alpha variants

Details C-terminally truncated interferon alpha variants C-terminally truncated interferon alpha variants

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A01H 5/00 (2006.01) C07K 14/56 (2006.01)

Patent

CA 2540884

The present invention provides biologically active variants of human .alpha.- 2b- interferon. The variants contain carboxy terminus truncations when compared with the amino acid sequence of full-length human .alpha.-2b- interferon. It is the novel finding of the present invention that these truncated variants have the biological activity of full-length human .alpha.- 2b-interferon. The invention encompasses these biologically active variant .alpha.-interferons, as well as polynucleotides encoding these interferons. Expression cassettes comprising these polynucleotides and host cells comprising the expression cassettes are also provided. The invention also provides compositions comprising variant .alpha.-interferon polypeptides and a pharmaceutically acceptable carrier.

Variants biologiquement actifs de l'interféron .alpha.-2b humain, qui comportent des terminaisons carboxy tronquées par comparaison à la séquence d'acides aminés de l'interféron .alpha.-2b humain de pleine longueur. Il a été découvert que ces variants tronqués possèdent l'activité biologique de l'interféron .alpha.-2b humain de pleine longueur. La présente invention concerne ces variants biologiquement actifs d'interféron .alpha.-2b humain, ainsi que des polynucléotides codant ces interférons. Des cassettes d'expression contenant ces polynucléotides et des cellules hôtes contenant ces cassettes d'expression sont également décrites. La présente invention concerne également des compositions contenant des polypeptides de ces interférons .alpha. variants et un excipient acceptable sur le plan pharmaceutique.

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