C1 inhibitor with short half-life for transient treatment

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/57 (2006.01) A61P 1/18 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 17/02 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2525522

The present invention relates to the use of a C1 inhibitor (C1INH) with shorter half-life than plasma-derived C1INH for the preparation of a medicament for the transient treatment of an individual. It relates to both therapeutic and prophylactic treatment. The method of the invention allows for the administration of C1INH at certain therapeutic levels for a concise pre- determined time span. Pharmaceutical compositions based on C1INH with shorter half-lives may be used both in situations where transient treatment is merely and advantage. The advantage of the use according to the invention is that an individual is not exposed to C1INH for longer than required, since the levels of the C1INH more rapidly subsides after administration has stopped. In contrast, levels of plasma-derived C1INH would remain elevated for a prolonged period of time.

L'invention porte sur l'utilisation d'un inhibiteur de C1 (C1INH) présentant une demi-vie plus courte que C1INH dérivé du plasma pour la préparation d'un médicament destiné au traitement transitoire d'un individu. Elle concerne les traitements à la fois thérapeutiques et prophylactiques. Le procédé selon l'invention permet l'administration de C1INH à certains niveaux thérapeutiques pour une durée prédéterminée brève. Des compositions pharmaceutiques à base de C1INH présentant des demi-vies plus courtes peuvent être utilisées dans des situations où le traitement transitoire est simplement un avantage. L'avantage de cette utilisation est qu'un individu ne soit pas exposé à C1INH plus longtemps que nécessaire puisque les niveaux de C1INH diminuent plus rapidement après l'arrêt de l'administration. En revanche, les niveaux de C1INH dérivé du plasma restent élevés pendant une durée prolongée.

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