C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/361.6, 260/3
C07D 307/56 (2006.01) C07D 307/68 (2006.01)
Patent
CA 1077051
Abstract of the Disclosure Substituted furoic acids and esters and pharmaceu- tically acceptable salts thereof of the following general structure are useful as hypolipidemic agents: Image wherein Y represents oxygen or divalent sulfur; R repre- sents a straight or branched alkyl chain containing from 10 to 20 carbon atoms and may be saturated or may be un- saturated containing from 1 to 4 double bonds; R1 repre- sents hydrogen, straight or branched lower alkyl of from 1 to 6 carbon atoms, benzyl, phenethyl, pyridylmethyl, alkane-poly-yl containing from 3 to 6 carbon atoms, 1,2, 3,4,5,6-cyclohexanehexayl, or Z; Z represents (A) the group Image wherein n is an integer of 2 or 3; R2 represents straight or branched lower alkyl of from 1 to 4 carbon atoms, or acyl; R3 represents hydrogen or straight or branched lower alkyl of from 1 to 4 carbon atoms with the proviso that when R3 is hydrogen, R2 is acyl; or when R2 is other than acyl, R2 and R3 taken together with the nitrogen atom to which each is attached form a monocyclic heterocyclic group, such as pyrrolldino, piperidino, morpholino, or plperazino; or -1- (B) the group Image wherein the sum of the Integers m and p is equal to from 3 to 5; and R4 represents straight or branched lower alkyl of from 1 to 4 carbon atoms; X Is an integer of from 1 to 6 with the proviso that when R1 is alkane-poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to from 2 to 6, and when R1 is other than alkane- poly-yl or 1,2,3,4,5,6-cyclohexanehexayl, X is equal to 1.
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