C10 carbonate substituted taxanes as antitumor agents

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 305/14 (2006.01) A61K 31/335 (2006.01) A61K 31/337 (2006.01) A61K 31/341 (2006.01) A61K 31/381 (2006.01) A61K 31/4427 (2006.01) A61K 31/443 (2006.01) A61K 31/4436 (2006.01) A61P 35/00 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2368151

Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

L'invention concerne des taxanes comportant un substituant carbonate en C(10), un substituant hydroxy en C(7) et une série de substituants en chaîne latérale situés en position C(2), C(9), C(14) et C(13).

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