C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61K 31/5575 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 27/06 (2006.01) C07D 257/04 (2006.01)
Patent
CA 2324343
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I): (see formula I) wherein R1, R2, R3, R4, R5, R6, W, X, Z, a, b, and p are defined below. This invention also includes optical isomers, diastereomers and enantiomers of the formula, and pharmaceutically- acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
L'invention se rapporte à de nouveaux analogues de prostaglandines, en particulier à des composés possédant une structure qui correspond à la formule suivante: (formule) R1, R2, R3, R4, R5, R6, W, X, Z, a, b et p étant définis dans la description de l'invention. L'invention concerne également des isomères optiques, des diastéréoisomères et des énantiomères correspondant à la formule ci-dessus ainsi que des sels pharmaceutiquement acceptables, des amides biohydrolisables, des esters et leurs imides. Les composés de la présente invention sont utilisés pour traiter toute une série de maladies et d'états tels que les troubles osseux et le glaucome, ainsi l'invention concerne-t-elle également des compositions pharmaceutiques comprenant ces composés. L'invention concerne en outre des traitements des troubles osseux et du glaucome au moyen de ces composés ou de compositions contenant ces derniers.
Amburgey Jack Snyder Jr.
De Biswanath
de Long Mitchell Anthony
Soper David Lindsey
Wos John August
Duke University
Kirby Eades Gale Baker
The Procter & Gamble Company
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