C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) A61K 31/557 (2006.01)
Patent
CA 2324590
The invention provides novel prostaglandin analogs. In particular, the present invention relates to compounds having a structure according to formula (I) wherein R1, R2, R3, R4, R5, R6, W, X, Z, a, b, p and q are defined below. This invention also includes optical isomers, diastercomers and enantiomers of formula (I), and pharmaceutically- acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
L'invention concerne de nouveaux analogues de prostaglandines et se rapporte notamment aux composés possédant la structure représentée par la formule (I) dans laquelle R1, R2, R3, R4, R5, R6, W, X, Z, a, b, p et q sont définis dans le descriptif. L'invention concerne aussi des isomères optiques, des diastéréo-isomères et des énantiomères correspondant à la formule (I), leurs sels pharmaceutiquement acceptables et leurs imides, esters et amides biohydrolisables. Les composés de l'invention sont utiles pour le traitement de divers états et maladies tels que les troubles osseux et le glaucome, aussi l'invention concerne-t-elle également des compositions pharmaceutiques comprenant ces composés. De plus, elle concerne des procédés de traitement des troubles osseux et du glaucome au moyen de ces composés ou des compositions qui les contiennent.
Amburgey Jack Snyder Jr.
De Biswanath
Delong Mitchell Anthony
Soper David Lindsey
Wos John August
Duke University
Kirby Eades Gale Baker
The Procter & Gamble Company
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