C12orf48 as a target gene for cancer therapy and diagnosis

Details C12orf48 as a target gene for cancer therapy and diagnosis C12orf48 as a target gene for cancer therapy and diagnosis

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01)

Patent

CA 2735145

Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them.

Linvention concerne des méthodes permettant de diagnostiquer une prédisposition au développement du cancer du pancréas et du cancer de la prostate, en particulier de ladénocarcinome canalaire pancréatique (ACP) et du cancer de la prostate résistant à castration. Dans un mode de réalisation, la méthode de diagnostic implique létape de détermination dun taux dexpression du gène C12ORF48 à laide dARNsi ciblant C12ORF48. Linvention concerne aussi des produits tels que les ARNsi ainsi que des compositions les renfermant. Linvention concerne par ailleurs des méthodes de criblage dagents thérapeutiques utilisés dans le traitement de pathologies associées avec le gène C12ORF48, comme le cancer (par exemple le cancer du pancréas et le cancer de la prostate) ainsi que des méthodes permettant dinhiber la croissance cellulaire et de traiter ou datténuer un ou plusieurs symptômes de la maladie. Linvention concerne également des produits tels que des molécules bicaténaires, des vecteurs et des compositions les renfermant.

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