C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 405/00 (2006.01) A61K 31/557 (2006.01) A61P 19/10 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2364948
The invention provides novel PGF analogs. In particular, the present invention relates to compounds having a structure according to formula (I), wherein R1, R2, X and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of formula (I), and pharamceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders using theses compounds or the compositions containing them.
La présente invention se rapporte à de nouveaux analogues de PGF, en particulier à des composés possédant la structure représentée par la formule (I) ci-après, dans laquelle R¿1?, R¿2?, X et Z sont tels que définis dans le descriptif. L'invention concerne également des isomères optiques, des diastéréo-isomères et des énantiomères de formule (I), leurs sels pharmaceutiquement acceptables, et leurs amides, esters et imides biohydrolysables. Les composés de la présente invention sont utilisés pour le traitement de divers états et maladies, notamment les troubles osseux. Aussi l'invention concerne-t-elle également des compositions pharmaceutiques renfermant ces composés. L'invention concerne, en outre, des méthodes de traitement des troubles osseux au moyen de ces composés ou des compositions qui les contiennent.
De Biswanath
Delong Mitchell Anthony
Soper David Lindsey
Wos John August
Duke University
Ledgley Law
The Procter & Gamble Company
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