C2orf18 as target gene for cancer therapy and diagnosis

Details C2orf18 as target gene for cancer therapy and diagnosis C2orf18 as target gene for cancer therapy and diagnosis

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/713 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2718382

Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.

La présente invention porte sur des procédés destinés à détecter ou à diagnostiquer une prédisposition au cancer, en particulier au cancer pancréatique. Dans un mode de réalisation, le procédé de diagnostic consiste à déterminer un taux d'expression de C2orf18 à l'aide d'un anticorps anti-C2orf18. De plus, la présente invention porte sur des procédés de criblage pour agents thérapeutiques utiles dans le traitement d'une maladie associée à C2orf18, telle qu'un cancer, par exemple un cancer pancréatique ; sur des procédés d'inhibition de la croissance cellulaire et de traitement ou de soulagement de leur symptôme. L'invention porte également sur des produits, tels que des polynucléotides, des polypeptides et des molécules double brin vecteurs, des anticorps, des vecteurs et des compositions les comprenant.

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