C5a receptor antagonists

Details C5a receptor antagonists C5a receptor antagonists

C - Chemistry, Metallurgy

07

C

C07C 275/40 (2006.01) A61K 31/17 (2006.01)

Patent

CA 2607862

The present invention is related to a compound, preferably a C5a receptor antagonist, having the following structure, Rl, R2, R3, R4, R5, R6, R7, R8, R9, Rl0, RI l, R12, R13, R14, R15, R16, Rl7, R18, Rl9, R20, R21 and R22 are individually and independently selected from the group comprising H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, alkoxyl, substituted alkoxyl, aryloxy, substituted aryloxy, arylalkyloxy, substituted arylalkyloxy, acyloxy, substituted acyloxy, halogen, hydroxyl, nitro, cyano, acyl, substituted acyl, mercapto, alkylthio, substituted alkylthio, amino, substituted amino, alkylamino, substituted alkylamino, bisalkyl amino, substituted bisalkyl amino, cyclic amino, substituted cyclic amino, carbamoyl (-CONH2), substituted carbamoyl, carboxyl, carbamate, alkoxycarbonyl, substituted alkoxycarbonyl, acylamino, substituted acylamino, sulfamoyl (- SO2NH2), substituted sulfamoyl, haloalkyl, haloalkyloxy, -C(O)H, trialkylsilyl and azido.

L'invention concerne un composé, de préférence un antagoniste du récepteur C5a, présentant la structure suivante, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21 et R22 étant individuellement et indépendamment sélectionnés dans le groupe comprenant H, alkyle, alkyle substitué, alcényle, alcényle substitué, alcynyle, alcynyle substitué, cycloalkyle, cycloalkyle substitué, hétérocyclyle, hétérocyclyle substitué, aryle, aryle substitué, hétéroaryle, hétéroaryle substitué, arylalkyle, arylalkyle substitué, hétéroarylalkyle, hétéroarylalkyle substitué, alcoxyle, alcoxyle substitué, aryloxy, aryloxy substitué, arylalkyloxy, arylalkyloxy substitué, acyloxy, acyloxy substitué, halogène, hydroxyle, nitro, cyano, acyle, acyle substitué, mercapto, alkylthio, alkylthio substitué, amine, amine substituée, alkylamine, alkylamine substituée, bisalkyle amine, bisalkyle amine substituée, amine cyclique, amine cyclique substituée, carbamoyle (-CONH2), carbamoyle substitué, carboxyle, carbamate, alcoxycarbonyle, alcoxycarbonyle substitué, acylamine, acylamine substituée, sulfamoyle (-SO2NH2), sulfamoyle substitué, haloalkyle, haloalkyloxy, -C(O)H, trialkylsilyle et azide.

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