C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-...

Details C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-... C63-amide derivatives of 34-de(acetylglucosaminyl)-34-deoxy-...

C - Chemistry, Metallurgy

07

K

530/9, 167/103.8

C07K 9/00 (2006.01) A61K 31/395 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 38/14 (2006.01) C07D 498/18 (2006.01) C07H 15/24 (2006.01) C07H 17/08 (2006.01) C07K 1/06 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2006379

ABSTRACT C63-AMIDE DERIVATIVES OF 34-DE(ACETYLGLUCOSAMINYL)-34-DEOXY-TEICOPLANINS. C63-Amide derivatives of 34-de(acetylglucosaminyl) -34-deoxy-teicoplanin wherein the amide moiety is derived from a di- or poly-amine. The derivatives are prepared by reacting 34-de(acetylglucosaminyl)- 34-deoxy-teicoplanins with an active esters forming reagent such as chloroacetonitrile and then contacting said active esters with the appropriate di- or poly-amine. The amide derivatives are active against Gram-positive microorganisms, in particular against Group A Streptococci.

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