C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12N 15/16 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2335643
The present invention relates to a newly identified potassium channel .beta.- subunit. The invention also relates to polynucleotides encoding the subunit. The invention further relates to methods using subunit polypeptides and polynucleotides, applicable to diagnosis and treatment in channel-mediated disorders. The invention further relates to drug-screening methods using the polypeptides and polynucleotides to identify agonists and antagonists, applicable to diagnosis and treatment. The invention further encompasses agonists, and antagonists based on the subunit polypeptides and polynucleotides. The invention further relates to procedures for producing the subunit polypeptides and polynucleotides.
La présente invention concerne une sous-unité bêta du canal à potassium nouvellement identifiée, et des polynucléotides codant ladite sous-unité. L'invention concerne également des procédés qui mettent en oeuvre les polypeptides et polynucléotides de ladite sous-unité et conviennent pour le diagnostic ou le traitement de troubles liés au canal. L'invention concerne en outre des procédés de criblage de médicaments qui mettent en oeuvre les polypeptides et polynucléotides de l'invention pour identifier des agonistes et des antagonistes, et conviennent pour des applications diagnostiques ou thérapeutiques. Elle concerne des agonistes et des antagonistes basés sur les polypeptides et polynucléotides de l'invention. L'invention concerne enfin des procédés de production des polypeptides et polynucléotides de ladite sous-unité.
Curtis Rory
Glucksmann Maria Alexandra
Millenium Pharmaceuticals Inc.
Millennium Pharmaceuticals Inc.
Torys Llp
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