Cacna1g polynucleotide, polypeptide and methods of use therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/11 (2006.01) C07H 21/04 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2388419

A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been observed that the methylation state of specific regions within CpG islands associated with the CACNA1G gene correlates with a number of cancerous phenotypes involving a variety of tissue and cell types. Also provided are methods for detecting cellular proliferative disorders by determining the methylation state of genes or regulatory regions associated therewith, including CACNA1G, as well as kits containing reagents for performing invention methods.

L'invention concerne un nouveau canal calcique de type T (CACNA1G), ainsi que des polynucléotides le codant. CACNA1G est impliqué dans les troubles de la prolifération cellulaire. D'une manière plus spécifique, il a été observé que l'état de méthylation de régions spécifiques au sein des îlots CpG associés au gène CACNA1G est en corrélation avec un nombre de phénotypes cancéreux concernant plusieurs types de tissus et de cellules. L'invention concerne également des procédés permettant de détecter les troubles de prolifération cellulaire consistant à déterminer l'état de méthylation de gènes ou de régions régulatrices associés, y compris CACNA1G ; ainsi que des kits contenant des réactifs pour mettre en oeuvre les procédés de l'invention.

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