C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2344266
The present invention relates to molecules involved in cell-cell interactions in the immune system. In particular, the invention relates to a cell surface protein which contains certain classical cadherin characteristics, but it exhibits an apical distribution pattern on the surface of lymphocytes. The membrane location of this molecule correlates with the contact interface between T and B cells, and antibodies against an extracellular domain of this protein disrupt T cell/B cell interactions.
La présente invention porte sur des molécules impliquées dans l'interaction de cellules du système immun. L'invention porte notamment sur une protéine de surface cellulaire qui comporte certaines caractéristiques classiques de la cadhérine, mais qui présente une distribution apicale sur la surface des lymphocytes. L'emplacement de la membrane de cette molécule est en corrélation avec l'interface entre les lymphocytes T et B, et les anticorps contre un domaine extracellulaire de cette protéine interrompent les interactions des lymphocytes T/B.
Davis Mark M.
Lu Peter S.
Fetherstonhaugh & Co.
The Board Of Trustees Of The Leland Stanford Junior University
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