Caged sensors, regulators and compounds and uses thereof

Details Caged sensors, regulators and compounds and uses thereof Caged sensors, regulators and compounds and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2505603

A number of caged (e.g., photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense nucleic acids, caged ribozymes, caged biomolecular analogs, caged transcription factors, caged antibodies, caged molecular decoys, and caged aptamers. Compositions comprising a plurality of caged components are also provided, as are labeled and optionally caged modulators. Also provided are kits for making the caged compositions and methods for making and for using the caged compositions. Related systems and devices are also provided (e.g., an uncaging device that can trigger photoactivatable assays and optionally detect signals from the assays).

L'invention concerne des compositions bloquées (p. ex. photoactivables) telles que, par exemple, des capteurs d'enzyme bloqués, des capteurs de liaison bloqués, des sondes d'acide nucléique bloquées, des ARN interférents bloqués, des acides nucléiques antisens bloqués, des ribozymes bloqués, des analogues biomoléculaires bloqués, des facteurs de transcription bloqués, des anticorps bloqués, des leurres moléculaires bloqués et des aptamères bloqués. L'invention concerne aussi des compositions contenant une pluralité de constituants bloqués, ainsi que des modulateurs marqués et éventuellement bloqués ; des trousses pour fabriquer les compositions bloquées ainsi que des procédés de fabrication et d'utilisation des compositions bloquées ; des systèmes et des dispositifs associés (p. ex. dispositif de déblocage pouvant déclencher des tests photoactivables et détecter éventuellement des signaux provenant de ceux-ci).

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