Calcification mitigation of bioprosthetic implants

Details Calcification mitigation of bioprosthetic implants Calcification mitigation of bioprosthetic implants

A - Human Necessities

01

N

A01N 1/02 (2006.01) A61L 27/00 (2006.01) A61L 27/36 (2006.01)

Patent

CA 2046592

Calcification resistant bioprosthetic implants are made from tanned biological materials, such as porcine heart valves, bovine pericardium, human dura mater or the like, which has been impregnated with a calcification-mitigating effective amount of a ferric and/or stannic salt, and having been treated with one or more diamines in combination with one or more activating factors. The impregnated biological materials and processes are particularly advantageous for the preparation of bioprosthetic heart valves. These implants have been found to be highly resistant to calcification in vivo.

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