Calcification-resistant bioprosthetic tissue and methods of...

Details Calcification-resistant bioprosthetic tissue and methods of... Calcification-resistant bioprosthetic tissue and methods of...

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 27/36 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2202247

Naturally-derived bioprosthetic materials are treated with epoxide crosslinking agents. In some embodiments, the tissue is crosslinked with low molecular weight epoxides in aqueous solutions at high pH levels. In other embodiments, the tissue is crosslinked at physiologic pH levels with epoxide crosslinking agents catalyzed with tertiary or quaternary amines, such as Tris or imidazole. In an advantageous embodiment, bioprosthetic tissue is crosslinked and derivatized with an anticalcification agent, such as a polyphosphonate anticalcification agent, using a polyphosphonate:polyepoxide monoadduct.

On traite des matériaux bioprothétiques d'origine naturelle avec des agents de réticulation à base d'époxydes. Dans certaines variantes, un tel tissu est réticulé avec des époxydes à faible poids moléculaire dans des solutions aqueuses et à des niveaux de pH élevés. Dans d'autres variantes, le tissu est réticulé à des niveaux de pH physiologiques, et les agents de réticulation à base d'époxydes sont catalysés avec des amines tertiaires ou quaternaires telles que Tris ou imidazole. Dans une variante avantageuse, le tissu bioprothétique est réticulé, et il donne un dérivé obtenu avec un agent anti-calcification, tel qu'un polyphosphonate, grâce à un produit de mono-addition, le polyphosphonate:polyépoxyde.

Affiliated with

Also associated with

Rating

Calcification-resistant bioprosthetic tissue and methods of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Calcification-resistant bioprosthetic tissue and methods of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Calcification-resistant bioprosthetic tissue and methods of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1441754