Calcification-resistant fixation

Details Calcification-resistant fixation Calcification-resistant fixation

C - Chemistry, Metallurgy

14

C

C14C 1/06 (2006.01) A61F 2/02 (2006.01) A61F 2/28 (2006.01) A61F 2/80 (2006.01) A61L 2/00 (2006.01) A61L 27/36 (2006.01) A61L 27/50 (2006.01)

Patent

CA 2473644

Non-glutaraldehyde fixation of an organ or a prosthesis for implantation in a mammal is based upon carbodiimide treatment. An aqueous solution containing a coupling agent, such as EDC, in combination with a coupling enhancer, such as sulfo-NHS, and a high concentration of a diamine cross-linking agent is used. As a result, only minimal surface reduction occurs during fixation, and the resultant products show a dramatic increase in resistance to calcification.

La fixation sans glutaraldéhyde d'un organe ou d'une prothèse à implanter chez un mammifère est fondée sur un traitement au carbodiimide. On utilise, à cet effet, une solution aqueuse contenant un agent de couplage, tel que du dichlorure d'éthylène (EDC), en combinaison avec un agent facilitant ce couplage, tel que le sulfo-NHS, et une forte concentration d'un agent de réticulation à base de diamine. Ainsi, une réduction de surface seulement minimale se produit au cours de la fixation et les produits obtenus présentent une résistance à la calcification considérablement accrue.

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