Calcification resistant synthetic biomaterials

Details Calcification resistant synthetic biomaterials Calcification resistant synthetic biomaterials

A - Human Necessities

61

L

A61L 27/00 (2006.01) A61L 27/14 (2006.01) A61L 27/18 (2006.01) A61L 27/36 (2006.01) A61L 27/50 (2006.01) A61L 33/00 (2006.01) C08F 8/40 (2006.01) C08G 18/83 (2006.01) C08G 59/14 (2006.01)

Patent

CA 2139872

2139872 9401481 PCTABS00030 Synthetic biomaterials are provided with irreversibly bound amino diphosphonate, polyphosphonate, or other anticalcification agent to prevent in vivo calcification. Such biomaterials include biocompatible elastomers such as polyurethane and/or polydimethylsiloxane, and the like which are intended for invasive, or indwelling use in a human or animal body. Illustratively, reaction conditions utilizing bi- or polyfunctional epoxides result in epoxide bridge incorporation of the anticalcification agent to the biomaterial elastomer.

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