Calcification resistant tissue for implantation

A - Human Necessities – 61 – F

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167/104, 167/327

A61F 2/24 (2006.01) A01N 1/02 (2006.01) A61L 27/36 (2006.01)

Patent

CA 1199277

-16- CALCIFICATION RESISTANT TISSUE FOX IMPLANTATION ABSTRACT Porcine valve cusp tissue and bovine pericardial tissue useful in the fabrication of prosethetic heart valves for implantation in humans, are characterized, in the case of porcine valve cusp tissue, by having an average degree of calcification of less than 1.0 µg Ca++/mg tissue after 8 weeks implantation in a Sprague-Dawley rat test. In the case of bovine pericardia tissue, average calcification is less than 2.5 µg after 8 weeks.

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