Calcitonin gene related peptide receptor antagonists

Details Calcitonin gene related peptide receptor antagonists Calcitonin gene related peptide receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/4427 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 49/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 25/06 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 471/10 (2006.01) C07D 487/22 (2006.01) C07D 491/10 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2487976

The presnt invention relates to compounds of Formula (I), as antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

L'invention concerne des composés de Formula (I), utilisés comme antagonistes des récepteurs du peptide relié au gène de la calcitonine ("récepteur CGRP"), des compositions pharmaceutiques renfermant ces composés, des procédés d'identification de ces composés, des méthodes de traitement utilisant ceux-ci et l'utilisation desdits composés dans la thérapie destinée au traitement de vasodilatations neurogènes, d'inflammations neurogènes, de migraines et d'autres maux de tête, de blessures thermiques, de chocs circulatoires, de bouffées de chaleur liées à la ménopause, de maladies inflammatoires des voies aériennes, telles que l'asthme et la broncho-pneumopathie chronique obstructive (BPCO) et d'autres états dont le traitement peut être effectué par l'antagonisme des récepteurs CGRP.

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