Calcitonin salmon analogues, their preparation, medicinal...

Details Calcitonin salmon analogues, their preparation, medicinal... Calcitonin salmon analogues, their preparation, medicinal...

C - Chemistry, Metallurgy

07

K

C07K 14/585 (2006.01) A61K 9/00 (2006.01) A61K 38/23 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 47/12 (2006.01) A61K 47/18 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2210664

(see figure I) (I) The present invention relates to novel substituted salmon calcitonin ( salcatonin ) analogues as indicated in formula (I) wherein R1 is -Cys-S-H or -Cys-S-OH or ester thereof or ethers of alkyl groups having from 2 to 5 carbon atoms or pharmaceutically acceptable salts or individual isomers thereof and R2 is hydrogen or hydroxy or esters thereof or ethers of alkyl groups having from 2 to 5 carbon atoms or pharmaceutically acceptable salts or individual isomers thereof or R2 is acetoamidomethyl or equivalents thereof.Their analogues have medicinal properties for the preventing or treatment of diseases such as ostcoporosis, hypercalcemia and Paget's disease and are useful as a reference for analytical testing.

L'invention porte sur de nouveaux analogues de la calcitonine de saumon substituée (salcatonine) de formule (I) dans laquelle R1 représente -Cys-S-H ou -Cys-S-OH, ou un de leurs esters, ou des éthers de groupes alkyle présentant 2 à 5 atomes de carbone, ou leurs sels pharmacocompatibles, ou leurs isomères individuels; et dans laquelle R2 représente soit hydrogène ou hydroxy, ou leurs esters, ou des éthers de groupes alkyle présentant 2 à 5 atomes de carbone, ou leurs sels pharmacocompatibles, ou leurs isomères individuels, soit acétoamidométhyle ou ses équivalents. Ces analogues présentent des propriétés médicales utiles pour la prévention ou le traitement de maladies telles que l'ostéoporose, l'hypercalcémie ou la maladie de Paget, et servent de référence pour les tests analytiques.

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