Calcium binding recombinant antibody against protein c

Details Calcium binding recombinant antibody against protein c Calcium binding recombinant antibody against protein c

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61P 7/04 (2006.01) A61P 35/00 (2006.01) C07K 16/46 (2006.01) C12N 9/50 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2192467

A Ca2+ dependent recombinant antibody that specifically binds to a specific twelve peptide sequence (E D Q V D P R L I D G K) in the activation region of the Protein C has been constructed. The antibody does not bind to Activated Protein C and can be used to inhibit activation of Protein C by thrombin-thrombomodulin, in purification of Protein C, and in treatment of tumors.

Anticorps recombiné dépendant du Ca<2+> et se liant spécifiquement à une séquence spécifique constituée de 12 peptides (E D Q V D P R L I D G K) dans la région d'activation de la protéine C. Cet anticorps ne se lie pas à la protéine C activée et peut être utilisé pour inhiber l'activation de la protéine C par la thrombine-thrombomoduline, pour la purification de la protéine C et dans le traitement des tumeurs.

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