Calcium blockers to treat proliferative vitreoretinopathy

Details Calcium blockers to treat proliferative vitreoretinopathy Calcium blockers to treat proliferative vitreoretinopathy

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/00 (2006.01)

Patent

CA 2295098

Glutamate causes migration and proliferation of retinal pigment epithelium and/or glial cells, and glutamate antagonists can prevent, treat or reduce retinal pigment epithelium and/or glial migration and the subsequent development of proliferative vitreoretinopathy. Avoidance or management of proliferative vitreoretinopathy can be achieved by administration to the patient a compound capable of reducing glutamate-induced retinal cell migration in a concentration effective to reduce such migration.

L'acide glutamique provoque la migration et la prolifération de l'épithélium pigmentaire de la rétine et/ou des cellules gliales et des antagonistes de l'acide glutamique peuvent empêcher, traiter ou limiter la migration de l'épithélium pigmentaire de la rétine et/ou des cellules gliales, ainsi que l'évolution consécutive de la vitréorétinopathie proliférative. On peut éviter ou gérer la vitréorétinopathie proliférative par administration au malade d'un composé dont la concentration permet de réduire la migration des cellules de la rétine provoquée par l'acide glutamique.

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