A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/453 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2223711
A method for antagonizing or blocking calcium channels in vascular tissue, comprising administering to an animal in need thereof a pharmaceutically- effective amount of a compound having formula (I) wherein R1 and R3 are independently hydrogen, C1-C4 alkyl, -CO-(C1-C6 alkyl), or -CH2Ar, -CO-Ar, wherein Ar is phenyl or substituted phenyl; R2 is selected from the group consisting of pyrrolidine, hexamethyleneimino, and piperidino; or a pharmaceutically-acceptable salt thereof.
L'invention concerne un procédé pour inhiber les canaux calciques dans les tissus vasculaires, consistant à administrer à un animal, dont l'état le requiert, une dose pharmaceutiquement efficace d'un composé ayant la formule (I) dans laquelle R?1¿ et R?3¿ sont indépendamment hydrogène, alkyle C¿1?-C¿4?, -CO-(alkyle C¿1?-C¿6?), ou bien -CH¿2?Ar, -CO-Ar, où Ar est phényle ou phényle substitué; R?2¿ est choisi dans le groupe composé de pyrrolidine, hexaméthylèneimino, et pipéridino; ou bien un sel pharmaceutiquement acceptable de ce composé.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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