Calcium channel blocking polypeptides from heteropoda venatoria

Details Calcium channel blocking polypeptides from heteropoda venatoria Calcium channel blocking polypeptides from heteropoda venatoria

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A01N 63/02 (2006.01) A61K 38/17 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146367

Polypeptides isolated from the venom of the Heteropoda venatoria spider block calcium channels in cells of various organisms and are useful in blocking said calcium channels in cells, per se, in the treatment of calcium channel-mediated diseases and conditions and in the control of invertebrate pests.

L'invention se rapporte à des polypeptides isolés provenant du venin de l'araignée Heteropoda venatoria qui bloquent les canaux calciques dans les cellules de divers organismes et qui servent par eux-mêmes d'inhibiteurs calciques dans les cellules, et sont utiles pour traiter les maladies et affections induites par les canaux calciques et à lutter contre la prolifération des insectes nuisibles invertébrés.

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