Calcium-containing structures and methods of making and...

A - Human Necessities – 61 – L

Patent

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Details

A61L 27/36 (2006.01) A61K 9/00 (2006.01) A61K 47/02 (2006.01) A61L 27/12 (2006.01) A61L 27/44 (2006.01) A61L 27/50 (2006.01) A61L 27/54 (2006.01) C12N 5/00 (2006.01) C12N 11/14 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2377747

The present invention generally relates to calcium-containing structures and methods of making and using the struc-tures. In one aspect, hollow calcium containing microstructures are used in conjunction with bone tissues/by-products to augment bone defects and extend the supply of bone tissues/by-products for bone augmentation. Bonding agents, such as calcium cements, are also used in the preparation of the hollow calcium microstructures combined with bone tissues/by-products or for use in preparing the hollow microstructures. The calcium-containing microstructures of the present invention are also useful as delivery vehicles of nitric oxide and/or nitric oxide containing or producing compounds for a variety of in vitro and in vivo uses. Calcium containing contoured substrates upon which cells/tissues can be grown in vitro for replacement and repair of tissues in vivo that conform in size and shape to the tissue surface to be replaced are also provided.

L'invention se rapporte de manière générale à des structures contenant du calcium et à des procédés de fabrication et d'utilisation de ces structures. Dans un aspect, des microstructures creuses contenant du calcium sont utilisées conjointement avec des tissus/sous-produits osseux pour renforcer des défauts osseux et étendre l'apport de tissus/sous-produits osseux à des fins de renforcement osseux. Des agents de liaison, tels que des ciments de calcium, sont également utilisés dans l'élaboration des microstructures creuses de calcium, seuls ou en combinaison avec des tissus/sous-produits osseux. Les microstructures contenant du calcium présentées dans l'invention sont aussi utiles comme vecteurs de monoxyde d'azote et/ou de composés contenant ou produisant du monoxyde d'azote pour diverses applications <i>in vitro</i> et <i>in vivo</i>. L'invention concerne également des substrats profilés contenant du calcium sur lesquels des cellules/tissus peuvent être cultivés <i>in vitro</i> à des fins de remplacement et de réparation de tissus <i>in vivo</i>, ces cellules/tissus s'adaptant du point de vue de la taille et de la forme à la surface de tissu à remplacer.

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