C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A23L 1/304 (2006.01) A61K 8/64 (2006.01) A61K 38/16 (2006.01) A61Q 11/00 (2006.01) C07K 7/06 (2006.01) C01B 25/32 (2006.01)
Patent
CA 2727634
The present invention is directed to novel complexes in which amorphous calcium phosphates are stabilised by phosphopeptides. The phosphopeptides contain the Ser(P) cluster sequence motif Ser(P)-Ser(P)-Ser(P)-Glu-Glu and can stabilise their own weight in amorphous calcium phosphate (ACP) [Ca3(PO4)1.87(HPO4)0.2xH2O] and amorphous calcium fluoride phosphate (ACFP) [Ca8(P04)5 F x H2O]. The amorphous phases stabilised by the phosphopeptides are an excellent delivery vehicle to co-localise Ca, F, and phosphate at the tooth surface in a slow-release amorphous form producing superior anticaries efficacy. These amorphous phases stabilised by the phosphopeptides also have utility as dietary supplements to increase calcium bioavailability and to help prevent diseases associated with calcium deficiencies.
Kirby Eades Gale Baker
The University Of Melbourne
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