Calcium flux as a pharmacoefficacy biomarker for inhibitors...

Details Calcium flux as a pharmacoefficacy biomarker for inhibitors... Calcium flux as a pharmacoefficacy biomarker for inhibitors...

A - Human Necessities

61

K

A61K 38/18 (2006.01)

Patent

CA 2683822

Described herein are methods for using calcium flux as a biomarker to select and predict patients likely to respond to an apoptotic agent as therapy. Further described herein is a method of using calcium flux as a clinical biomarker to determine whether a tumor is sensitive to an HDAC inhibitor.

La présente invention concerne des procédés d'utilisation de flux de calcium en tant que biomarqueur pour sélectionner et prédire des patients susceptibles de réagir à un agent apoptotique comme traitement. L'invention concerne également un procédé d'utilisation de flux de calcium en tant que biomarqueur clinique pour déterminer si une tumeur est sensible à un inhibiteur de HDAC.

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